Immunomodulation in transfused trauma patients
نویسندگان
چکیده
منابع مشابه
The impact of platelet transfusion in massively transfused trauma patients.
BACKGROUND The impact of platelet transfusion in trauma patients undergoing a massive transfusion (MT) was evaluated. STUDY DESIGN The Institutional Trauma Registry and Blood Bank Database at a Level I trauma center was used to identify all patients requiring an MT (≥10 packed red blood cells [PRBC] within 24 hours of admission). Mortality was evaluated according to 4 apheresis platelet (aPLT...
متن کاملTRANSFUSION MEDICINE Brief report The TNF ( 308A) polymorphism is associated with microchimerism in transfused trauma patients
Microchimerism (MC), defined as the persistence of allogeneic cells at low concentrations, is well documented in transfused trauma patients. We hypothesized that genetic polymorphisms linked to cytokine production could contribute to trauma-induced immune modulation and development of microchimerism after transfusion of trauma patients. We used high-throughput SYBR-green-based genotyping of sin...
متن کاملTEG-guided resuscitation is superior to standardized MTP resuscitation in massively transfused penetrating trauma patients.
BACKGROUND For nearly a decade, our center performed thromboelastograms (TEGs) to analyze coagulation profiles, allowing rapid data-driven blood component therapy. After consensus recommendations for massive transfusion protocols (MTPs), we implemented an MTP in October 2009 with 1:1:1 ratio of blood (red blood cells [RBC]), plasma (fresh-frozen plasma [FFP]), and platelets. We hypothesized tha...
متن کاملThe impact of blood product ratios in massively transfused pediatric trauma patients.
BACKGROUND Few studies have examined the impact of balanced resuscitation in pediatric trauma patients requiring massive transfusions. Adult data may not be generalizable to children. METHODS Retrospective analysis assessed patients seen at a level I trauma center between 2003 and 2010 aged ≤18 years requiring massive packed red blood cell (PRBC) transfusion, defined as transfusion of ≥50% to...
متن کاملThe TNF (-308A) polymorphism is associated with microchimerism in transfused trauma patients.
Microchimerism (MC), defined as the persistence of allogeneic cells at low concentrations, is well documented in transfused trauma patients. We hypothesized that genetic polymorphisms linked to cytokine production could contribute to trauma-induced immune modulation and development of microchimerism after transfusion of trauma patients. We used high-throughput SYBR-green-based genotyping of sin...
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ژورنال
عنوان ژورنال: Current Opinion in Anaesthesiology
سال: 2013
ISSN: 0952-7907
DOI: 10.1097/aco.0b013e32835d7160